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Fig. 2 | BMC Neuroscience

Fig. 2

From: Scutellarin regulates microglia-mediated TNC1 astrocytic reaction and astrogliosis in cerebral ischemia in the adult rats

Fig. 2

Scutellarin enhanced GFAP (A1A3), Notch-1 (B1B3), NICD (C1C3), HES-1 (D1D3), nestin (E1E3) and TNF-α (A13) expression in TNC1 via BV-2-conditioned medium. Moderate GFAP expression was detected in TNC1 incubated in CM; also, Notch-1, NICD, HES-1, nestin and TNF-α (B1, C1, D1, E1, F1) was weakly expressed. The expression however was enhanced in CM + L (B2, C2, D2, E2, F2). Upon treatment with CM + SL for 24 h, expression of all markers was drastically increased being more pronounced for NICD (C3) and nestin (E3). Note TNC1 astrocytes project long cytoplasmic processes with expansions (A3, D3, F3). Scale bars 20 μm

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