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Table 1 Examples of research design B nested data in biological neuroscience

From: Multilevel analysis quantifies variation in the experimental effect while optimizing power and preventing false positives

Example

Individual observations from

Clustered in

Experimental variable

Experimental effect

Effect of a growth factor on neurite outgrowth

Neurons

Animals

Growth factor yes/no

Difference in neurite outgrowth

Effect of neurite location (axon/dendrite) on traveling speed of intracellular vesicles

Intracellular vesicles

Neurons

Axon or dendrite

Difference in travelling speed

Effect of neuron type (interneurons/projection neurons) on electrophysiological properties

Neurons

Animals

Neuron type

Difference in electrophysiological properties

Effect of spine morphological features on synapse compartmentalization

Spines

Neurons

Morphological type

Difference in synapse compartmentalization