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Fig. 5 | BMC Neuroscience

Fig. 5

From: The vulnerability of thalamocortical circuitry to hypoxic-ischemic injury in a mouse model of periventricular leukomalacia

Fig. 5

A working model illustrating the thalamocortical circuitry and the affected targets in the contralateral versus ipsilateral side of the brain in a mouse model of PVL. NG2 cells are represented in the white matter and in the cerebral cortex. The synaptic contacts between vGluT2 labeled terminals from thalamocortical (TC) cells (termed “TC vGluT2” cells) are formed in the developing white matter and the cerebral cortex. These synapses are altered in PVL mice, which may in turn affect the myelination of layer VI pyramidal (P) cells (termed “P vGluT1” cells) that may then change vGluT1 expression in their axon terminals in the VP and RTN (indicated by red crosses)

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