Reduced task-related functional connectivity during a set-shifting task in unmedicated early-stage Parkinson’s disease patients

Table 3 Results of the gPPI analyses in the contrast “successful shift > successful repeat”: left PPC and right PPC

Regions	BA	t-value	Cluster size	Peak voxel coordinates (MNI)
Regions	BA	t-value	Cluster size	X	Y	Z
Left PPC
Positive coupling PD
Precuneus	31	3.61	77	3	−61	22
Positive coupling HC
Left angular gyrus	39	4.73	157	−45	−73	25
		4.56		−39	−67	22
		3.80		−57	−61	16
Precuneus	31	4.62	332	−3	−58	22
		4.04		−12	−55	28
		3.92		−12	−64	22
Left DMPFC	9	3.75	30	−6	50	37
Left DLPFC	9	3.64	157	−15	44	37
Right PPC
Positive coupling PD
Precuneus	31	3.96	36	6	−58	22
Positive coupling HC
Left angular gyrus	39	4.42	79	−51	−70	28
		4.10		−45	−79	25
		3.48		−39	−67	25
Precuneus	31	4.20	138	−3	−64	22
Precuneus		4.16		−6	−52	40
Left DMPFC	9	3.67	10	−3	53	34

Results of the connectivity analyses: comparison of the PD and HC groups on the successful shift > successful repeat contrast. All areas were significant at an uncorrected threshold of p < .001, with an extent threshold of 10 voxels
HC healthy controls, PD Parkinson’s disease, BA Brodmann area

ISSN: 1471-2202