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Fig. 3 | BMC Neuroscience

Fig. 3

From: Developmental interneuron subtype deficits after targeted loss of Arx

Fig. 3

Calbindin immunohistochemistry at 2 embryonic time points reveals a shift in location of Calbindin positive cells. A–A″ Upper row, presents coronal sections at e14.5. In the control, Calb positive cells are present primarily ventrally in the POA and the developing amygdala complex (bar with ends) and sparsely in the cortex. In the mutants (A′–A″) there is an increase in expression in the SVZ of the GE (asterisk) and throughout the developing BG. A few cells still migrate into the cortex, though primarily in the IZ. B–B″ Lower row, presents coronal sections at e18.5. In the control, Calb positive cells are present primarily ventrally in the developing amygdala complex (bar with ends) and cortex (brackets), and sparsely in the BG (asterisk). In the mutants (B′–B″) there is an increase in expression in the BG (asterisk) and a significant loss in the cortex (brackets), and no changes in the developing amygdala (bar with ends). C Displays the quantification of Calbindin positive cell numbers from embryonic ages. All counts are presented as average ranking from rostral and caudal (and dorsal and ventral) sections at e14.5 (upper) and e18.5 (lower). LV lateral ventricle, VZ ventricular zone, BG basal ganglia, Cx developing cortex, IZ intermediate zone, Hip hippocampus. L1 cortical layer 1, L2/3 cortical layers 2 and 3, L6 cortical layer 6

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