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Fig. 7 | BMC Neuroscience

Fig. 7

From: Developmental interneuron subtype deficits after targeted loss of Arx

Fig. 7

Parvalbumin immunohistochemistry at 2 postnatal time points revels altered expression patterns in hippocampus and cortex. Top row (P14 cortex, A–A″) demonstrates an increase in Parv positive cells in the cortex of Arx −/y ;Dlx5/6 CIG with no change in the Arx +/−female animals. The hippocampus at P14 (second row, B–B″) reveals a consistent decrease in Parv expression in the Arx −/y ;Dlx5/6 CIG male but not Arx +/−female. Asterisks denote significant differences. In the adult, there was a consistent trend toward a decrease between Arx +/−female and wildtype male in both the cortex (third row; C–C′) and hippocampus (last row, D–D′). E, F Display the quantification of Parv positive cell numbers from P14 (E) and adult (F) measuring the percent change from control in both the cortex and ippocampus. LV lateral ventricle, WM white matter, Cx developing cortex, Hip hippocampus. L1 cortical layer 1, L2/3 cortical layers 2 and 3, L6 cortical layer 6, DG dentate gyrus, CA1–CA3 Cornus Ammonis regions 3 and 1

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