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Fig. 6 | BMC Neuroscience

Fig. 6

From: The GLP-1 receptor agonists exendin-4 and liraglutide alleviate oxidative stress and cognitive and micturition deficits induced by middle cerebral artery occlusion in diabetic mice

Fig. 6

Effects of exendin-4 on MCAO-induced motor and cognitive deficits in db/db mice at 12 h (h), 3 and 7 days (d) after MCAO. a, a1a4 Experimental design and representative activity traces of control, b, b1b4 MCAO-injured, and c, c1c4 MCAO-injured mice treated with Ex-4 at 12 h, 3 days, and 7 days after injury. Motor parameters were (a1, b1, c1) velocity calculated using the body center trace and (a2, b2, c2) elongation ratio; cognitive parameters were (a3, b3, c3) non-target and (a4, b4, c4) target sniffing bousts. Groups were compared using two-way ANOVA with a post hoc Bonferroni adjustment for pairwise comparisons. *P < 0.05 compared to the time-matched control group; a P < 0.05 compared to the time-matched MCAO group; b P < 0.05 compared to MCAO + Ex-4 group at 12 h after injury

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