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Fig. 3 | BMC Neuroscience

Fig. 3

From: The preventive effect of resiniferatoxin on the development of cold hypersensitivity induced by spinal nerve ligation: involvement of TRPM8

Fig. 3

Effect of resiniferatoxin (RTX) pretreatment on the withdrawal latency to cold stimuli. Perineural administration with vehicle or RTX (0, 0.1, and 1 µg) was performed before spinal nerve ligation (SNL). Behavioral tests were performed before surgery and weekly for 4 weeks after SNL. To test cold allodynia, response to cold stimuli was examined using the 10 °C cold-plate (Ugo-Basile, Varese, Italy). The reaction time starting from the placement of the rat on the cold-plate to the time of licking or withdrawing the hind paw was measured. The cut-off time for the cold-plate test was set at 100 s. The data are presented as the mean ± standard error. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001 compared to the RTX 0 µg group

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