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Fig. 8 | BMC Neuroscience

Fig. 8

From: The preventive effect of resiniferatoxin on the development of cold hypersensitivity induced by spinal nerve ligation: involvement of TRPM8

Fig. 8

Number of immunoreactive neurons in the ipsilateral L5 dorsal root ganglion (DRG) positive for transient receptor potential melastatin type 8 (TRPM8). Compared with sham operated animals, spinal nerve ligation (SNL) demonstrated an increased trend in number of neurons positive for TRPM8 4 weeks after surgery (a). Pretreatment with 1 µg of resiniferatoxin (RTX) decreased the number of neurons presenting TRPM8 compared with the SNL group. The number of neurons coexpressing TRPM8 and neurofilament 200 were also increased in the SNL group compared with the sham group or SNL + RTX group (b). Three rats in each group were analyzed

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BMC Neuroscience

ISSN: 1471-2202

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