Hysteretic behavior of bladder afferent neurons in response to changes in bladder pressure

BMC Neuroscience

Table 1 Quantification of hysteresis from bladder pressure/tension-bladder afferent plots in published literature

References	Figure # and trace #	Animal model	Neural source and signal type	Bladder volume	Test state	Hmax	Hmean
Bruns [23]	5—unit 3 ρ: 0.71	Cat	S1 and S2 DRG	20 ml	None, bladder at isovolumetric state	0.65	0.43
Bruns [23]	5—unit 4 ρ: 0.68	Cat	S1 and S2 DRG	20 ml	None, bladder at isovolumetric state	0.87	0.71
Downie [8]^#	7A⁺⁺	Cat	Pelvic nerve filament	NR	Distension/withdrawal cycles under volume-step conditions	0.57	0.25
Downie [8]^#	7D	Cat	Pelvic nerve filament	NR	Distension/withdrawal cycles under pressure-step conditions	0.48	0.20
Jezernik et al. [35]	7—1st cycle	Pig	Pelvic ENG	Empty	60 ml bolus injection/withdrawal at 116 ml/min fill rate	0.52	0.34
Jezernik et al. [35]	7—2nd cycle	Pig	Pelvic ENG	Empty	60 ml bolus injection/withdrawal at 133 ml/min fill rate	0.77	0.49
Winter et al. [16]	2—unit 1	Cat	Detrusor afferent	Up to 10 ml	5 ml bolus injection/withdrawal	0.72	0.31
	2—unit 2	Cat	Detrusor afferent	Up to 10 ml	5 ml bolus injection/withdrawal	0.71	0.35
	2—unit 3	Cat	Detrusor afferent	Up to 10 ml	5 ml bolus injection/withdrawal	0.60	0.35
	2—unit 4	Cat	Detrusor afferent	Up to 10 ml	5 ml bolus injection/withdrawal	0.68	0.40

NR not reported
Hmax and Hmean values are average values (across multiple loops per unit) for Ref. [16] and [23]
^# Firing rate versus tension on bladder surface, not pressure
⁺⁺ The hysteresis relationship was opposite in direction than normal

ISSN: 1471-2202