Fig. 3From: Neural hyperactivity in the amygdala induced by chronic treatment of rats with analgesics may elucidate the mechanisms underlying psychiatric comorbidities associated with medication-overuse headacheRepresentative cortical spreading depression DC potential response to KCl applied onto the dura mater of rats chronically treated with acetaminophen or aspirin, and saline-treated control rats. The lower panel compares variables including peak amplitude, duration, latency, and number, and area under the curve. *P < 0.05 compared with the CSD response in saline-treated control rats, one-way ANOVA followed by a Dunnett testBack to article page