Fig. 4From: Neural hyperactivity in the amygdala induced by chronic treatment of rats with analgesics may elucidate the mechanisms underlying psychiatric comorbidities associated with medication-overuse headacheCortical spreading depression-evoked Fos-immunoreactive neurons in the trigeminal nucleus caudalis of rats chronically treated with acetaminophen or aspirin, and normal saline-treated control rats (scale bar 100 μm). The graph presents a statistical analysis of Fos-immunoreactive neurons (mean ± SD of counts per slide from 10 rats). *P < 0.05 compared with saline-treated control rats, one-way ANOVA followed by a Dunnett test. † P < 0.05 between aspirin and acetaminophen treated rats, one-way ANOVA followed by a Dunnett testBack to article page