Fig. 4From: Effect of Spp1 on nerve degeneration and regeneration after rat sciatic nerve injurySpp1 knockdown and overexpression affect SC apoptosis. a, b Silencing Spp1 by transfection with Spp1 siRNA significantly induces apoptosis of SCs compared with that in negative controls (NC). c, d Overexpression of Spp1 in SCs by transfection with the pcDNA3.1-Spp1 plasmid significantly inhibits SC apoptosis compared with that in NCs. e Relative numbers of SCs with the Spp1 knockdown. f Relative numbers of SCs overexpressing Spp1. The average of three independent experiments is shown as mean ± SEM (*p < 0.05)Back to article page