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Fig. 7 | BMC Neuroscience

Fig. 7

From: Lateral cortical Cdca7 expression levels are regulated by Pax6 and influence the production of intermediate progenitors

Fig. 7

Raising Cdca7 levels in E12.5 lateral cortex affects the production of Tbr2- and Tbr1-expressing cells. Brains electroporated with either the control or Cdca7 plasmid at AD, KN E12.5 and FI E14.5 reacted for AD, FI Tbr2 or KN Tbr1. B′, D′, G′, I′, L′, N′ High magnification of the areas outlined in B, D, G, I, L, N. Arrows point to cells co-labelled with Tbr2/Tbr1 and GFP and B″, G″ and L″ show magnified examples. E The frequencies of Tbr2+ cells in the population of GFP+ cells after E12.5 electroporation (mean ± SEM; control, n = 4: Cdca7, n = 3): the proportion in the Cdca7 group is significantly lower than that in the control group (p < 0.05, Student’s t-test). J The frequencies of Tbr2+ cells in the population of GFP+ cells after E14.5 electroporation (mean ± SEM; control, n = 3: Cdca7, n = 4): there is no significant difference (Student’s t-test). O The frequencies of Tbr1+ cells in the population of GFP+ cells after E12.5 electroporation (mean ± SEM; control, n = 4: Cdca7, n = 3): the proportion in the Cdca7 group is significantly lower than that in the control group (p < 0.05, Student’s t-test). All scale bars 50 µm

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