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Table 3 Biomarkers significantly upregulated by vortioxetine in rat frontal cortex (VEH vs. VOR)

From: Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents

Gene name

Protein ID

Un-corrected p value <0.05

Cacng2

CCG2

0.0173

Cacng6

CCG6

0.0173

Cacng8

CCG8

0.0173

Grik4

GRIK4

0.0095

Grik5

GRIK5

0.0095

Grm1

GRM1

0.0095

Grm5

GRM5

0.0095

Grm7

GRM7

0.0095

Homer3

HOMER3

0.0095

Htr1b

5-HT1B

0.0173

Mtor

MTOR

0.0317

Ppp1r9b

Spinophilin/NEB2

0.0303

Prkca

KPCA

0.0303

Syn3

SYN3

0.0317

  1. Significance is determined relative to VEH (saline) treatment (n = 5 animals for VEH; n = 6 animals for VOR). Due to the lower sample size, significance was not achieved following correction for multiple testing and thus, significant targets before correction were determined. A total of 14 targets were significantly modulated in response to VOR treatment and used as inputs in the network analysis