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Fig. 1 | BMC Neuroscience

Fig. 1

From: Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma

Fig. 1

Indicators of cytoskeletal associated proteins assessed immunohistochemically in the ventral optic nerve at days 1 and 7 following partial transection (PT) injury. a The ratio of Tau p[S396] to total Tau immunoreactivity was calculated using mean ± SEM area above set threshold for each protein and quantified from normal optic nerve and at days 1 and 7 following partial transection; b representative images from normal optic nerve shows Tau p[S396] (green) and total Tau (red) with overlay, arrows indicate an example of co-localisation. c Similarly, the mean ± SEM ratio of Tau p[T205] to total Tau; and d the ratio of Tau p[S262] to total Tau ± SEM. e Mean ± SEM area above threshold of acetylated tubulin immunoreactivity; f mean ± SEM area above threshold of NogoA immunoreactivity. g, h Representative images from normal optic nerve show acetylated tubulin (red) and NogoA (green) respectively. Significant differences are indicated by *p < 0.05, **p < 0.01 and ***p < 0.001; b scale bar = 25 µm; g, h scale bar = 50 µm

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