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Fig. 3 | BMC Neuroscience

Fig. 3

From: Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma

Fig. 3

Effects of combinations of ion channel inhibitors on node/paranode complexes. Mean ± SEM a length of the paranodal gap, indicative of node length; b paranode length and c AnkG+ length were quantified from normal, or injured vehicle or inhibitor treated animals, 3 days following partial optic nerve transection. Significant differences relative to vehicle are indicated by *p ≤ 0.05. d Representative images show Caspr immunopositive paranodes (green) and AnkG immunopositive structures within the node of Ranvier (red); scale bar = 5 µm. e A representative orthogonal z-projection of Caspr immunopositive paranodes (green) and AnkG immunopositive structures within the node of Ranvier (red) from normal ventral optic nerve; scale bar = 5 µm

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