Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma

BMC Neuroscience

Table 2 Summary of outcomes following partial transection injury and treatment with combinations of ion channel inhibitors to inhibit VGCCs, Ca²⁺ permeable AMPARs and/or P2X₇Rs at 3 days after injury

Ion channels inhibited	Vehicle	VGCC	VGCC + Ca²⁺ permeable AMPAR	VGCC + P2X₇R	VGCC + P2X7R + Ca²⁺ permeable AMPAR
Outcome measure
Visual function	↓	~	~	~	~
Tau[pS³⁹⁶]/total Tau	↑	↓	↓	↓	↓
Tau[pT²⁰⁵]/total Tau	↑	↓	↓	↓	↓
Acetylated tubulin	↑	–	–	↓	↓
NogoA	↓	↑	↑	↑	↑
MBP	↑	↓	~	↓	~
Paranodal gap length	↑	↓	↓	↓	↓
Paranode length	↑	↓	~	↓	↓
Ankyrin G length	↑	–	~	~	↓
Microglia/macrophages	↑	~	~	~	~
Acrolein	↑	~	~	~	~
HNE	~	~	~	~	↓
OPCs	↓	~	~	~	↑
8OHDG	↑	↑	↑	↑	~
CML	↑	~	~	~	~
3NT	↑	↓	~	~	~
MnSOD	↑	↓	~	~	↓

Symbols for vehicle treated animals indicate direction of change from normal untreated animals. Following treatment with ion channel inhibitors, significant decreases relative to injured animals treated with vehicle are shown as ↓, significant increases as ↑, remaining significant differences to normal are indicated by—(p ≤ 0.05) and intermediate outcomes not significantly different from vehicle treated or normal as ~(p > 0.05)

ISSN: 1471-2202