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Fig. 4 | BMC Neuroscience

Fig. 4

From: The loss-of-function disease-mutation G301R in the Na+/K+-ATPase α2 isoform decreases lesion volume and improves functional outcome after acute spinal cord injury in mice

Fig. 4

AQP4 protein levels in naïve and SCI-treated α +/+2 and α +/G301R2 mice. a AQP4 protein levels in naïve conditions and 3 days after SCI were evaluated in spinal cord lysates from α +/+2 and α +/G301R2 mice by Western blot analysis (b). Data are normalized to GAPDH protein expression, with no difference between genotypes or treatment (Tukey’s multiple comparisons test, naïve α +/+2 verus SCI-treated α +/+2 , α +/G301R2 and naïve α +/G301R2 p = 0.96, p = 0.71 and p = 0.95, respectively, and SCI-treated α +/+2 versus naïve and SCI-treated α +/G301R2 , p = 0.43 and p = 0.74, respectively, and naïve α +/G301R2 versus SCI-treated α +/G301R2 , p = 0.94) (n = 4 animal/group). c Immunohistochemical staining for AQP4 was comparable between α +/+2 and α +/G301R2 mice 3 days after SCI. Analysis was based on five sections from each animal, n = 4 mice/group. Scale bars low magnification = 200 μm; high magnification = 50 μm

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