Fig. 7

Synaptic transmission and plasticity are enhanced in male PDE4B1-D564A transgenic mice. Data are mean ± SE; asterisks (*) show data from the transgenic mice that is statistically different from that obtained from wild-type mice. a Baseline synaptic transmission shown with input–output curves for wild-type (WT) and PDE4B1-D564A (TG) male mice. b Paired-pulse facilitation in hippocampal slices. c Long-term potentiation (LTP) induced with a pair of 100-Hz tetani in area CA1. The arrows indicate the delivery of 2 trains of 100-Hz, 1-s stimulation. d Representative traces obtained 4 min before (black), and 2 h after LTP (gray), in wild-type (WT) and PDE4B1-D564A (TG) male mice