Fig. 1From: RETRACTED ARTICLE: Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer’s diseaseCurcumin or SLCP cross the blood brain barrier and binds with amyloid plaques. After intraperitoneal injections of Cur or SLCP (50 mg/kg), the 5xFAD brains were sectioned and images were taken from DG area of hippocampus using a fluorescent microscope with green filters. a Both Cur and SLCP permeated into the brain tissue, and SLCP appeared to be more permeable than Cur, and those receiving 5 days of treatment appeared to have more Cur in the brain than those receiving only 2 days of injections. b Images of sections from the DG area of the hippocampus in the Cur- or SLCP-treated mice were immunolabeled with Aβ-specific antibody (6E10) as observed by using a fluorescent microscope with green and red filters. Cur or SLCP colocalized with 6E10, confirming the green signal coming from Aβ plaques upon binding with Cur or SLCP. Red arrows: Cur or SLCP bound to the Aβ plaque; green arrow: 6E10 bound to Aβ plaque; and white arrow: merged images of Cur or SLCP and 6E10 with Aβ plaque. Scale bars indicate 250 µm and is applicable to other imagesBack to article page