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Fig. 1 | BMC Neuroscience

Fig. 1

From: Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer’s disease

Fig. 1

Curcumin or SLCP cross the blood brain barrier and binds with amyloid plaques. After intraperitoneal injections of Cur or SLCP (50 mg/kg), the 5xFAD brains were sectioned and images were taken from DG area of hippocampus using a fluorescent microscope with green filters. a Both Cur and SLCP permeated into the brain tissue, and SLCP appeared to be more permeable than Cur, and those receiving 5 days of treatment appeared to have more Cur in the brain than those receiving only 2 days of injections. b Images of sections from the DG area of the hippocampus in the Cur- or SLCP-treated mice were immunolabeled with Aβ-specific antibody (6E10) as observed by using a fluorescent microscope with green and red filters. Cur or SLCP colocalized with 6E10, confirming the green signal coming from Aβ plaques upon binding with Cur or SLCP. Red arrows: Cur or SLCP bound to the Aβ plaque; green arrow: 6E10 bound to Aβ plaque; and white arrow: merged images of Cur or SLCP and 6E10 with Aβ plaque. Scale bars indicate 250 µm and is applicable to other images

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