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Fig. 2 | BMC Neuroscience

Fig. 2

From: Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer’s disease

Fig. 2

Acute treatment of either Cur or SLCP reduced Aβ plaque loads in 5xFAD mice brain. a The 5xFAD mice were treated with Cur or SLCP for 2- or 5-days, sacrificed, and their brains were sectioned on a cryostat and stained with Cur, which labeled the Aβ plaques that were observed in the PFC and the DG area of the hippocampus. Scale bar indicates 250 µm and is applicable to the other images. b Cur binds to Aβ plaques in a manner similar to Aβ-specific antibody (6E10), so it was used for labeling and counting Aβ plaques in this study. Scale bar indicates 100 µm and is applicable to the other images. c, d The number of Aβ plaques were significantly decreased (**p < 0.01) in both the PFC (c) and the DG area of the hippocampus (d) in comparison to untreated 5xFAD mice

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