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Fig. 3 | BMC Neuroscience

Fig. 3

From: Characterisation of Zika virus infection in primary human astrocytes

Fig. 3

Replication of ZIKV in astrocytes, 48 h p.i. A The cytoplasm filled with numerous vacuoles containing neurosecretory vesicles (details in insets). B 3D model of the replication site. C, D Putative budding event—virus-induced vesicle with the nucleocapsid is connected (black arrow) to the neighbouring cisternae of the rough endoplasmic reticulum. Newly formed virion (white arrow) is located below the channel. E, F Microtubule associated to the two cisternae of the rough endoplasmic reticulum. G Cytoplasm of uninfected cells was filled with numerous vesicles. Bars: 2 µm (A, G), 200 nm (B), 100 nm (A-inset, D), and 50 nm (C, E, F)

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