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Table 1 Regulated genes involved in oxidative stress in all experimental groups classified by gene ontology

From: Neuroprotective dobutamine treatment upregulates superoxide dismutase 3, anti-oxidant and survival genes and attenuates genes mediating inflammation

Genes related to oxidative stress

Ctrl versus Ctrl D

Ctrl versus LPS

Ctrl versus OGD

OGD versus OGD D

LPS versus LPS D

LPS OGD versus LPS D OGD

Aco2, Aconitase 2, mitochondrial

3.6

     

Txndc11, Thioredoxin domain containing 11

3.2

   

2.8

 

Oxnad1, Oxidoreductase NAD-binding domain containing 1

3.0

     

Coq10b, Coenzyme Q10 homolog B (S, cerevisiae)

2.6

     

Sod3, Superoxide dismutase 3, extracellular

2.5

  

9.6

 

3.2

Srxn1, Sulfiredoxin 1 homolog (S, cerevisiae)

2.5

   

2.4

 

Txnrd1, Thioredoxin reductase 1

2.3

     

Ncf2, Neutrophil cytosolic factor 2

2.1

     

Sesn2, Sestrin 2

2.1

     

Vav1, Vav 1 oncogene

0.5

     

Cybb, Cytochrome b-245, beta polypeptide

0.4

7.6

  

0.5

 

Ncf1, Neutrophil cytosolic factor 1

0.4

     

Syk, Spleen tyrosine kinase

 

2.9

    

Nfe2l1, Nuclear factor, erythroid derived 2,-like 1

 

2.4

    

Sod2, Superoxide dismutase 2, mitochondrial

 

2.3

    

Naprt1, Nicotinate phosphoribosyltransferase domain containing 1

 

0.5

    

Txnip, Thioredoxin interacting protein

 

0.5

    

Sesn1, Sestrin 1

 

0.4

    

Nxn, Nucleoredoxin

 

2.2

    

Hmox1, Heme oxygenase 1

  

0.2

 

0.4

 

Oxnad1. Oxidoreductase NAD-binding domain containing 1

    

3.1

 

Hspa5. Heat shock 70 kD protein 5

    

2.5

 

Hspb1. Heat shock protein 1

    

2.1

 

Ncf1. Neutrophil cytosolic factor 1

    

0.5

 

Cdo1, Cysteine dioxygenase 1, cytosolic

     

2.1

Xdh, Xanthine dehydrogenase

     

0.5

Gstt1, Glutathione S-transferase, theta 1

     

0.4

  1. D dobutamine, LPS lipopolysaccharide, OGD oxygen–glucose-deprivation