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Table 5 Univariate and multivariate analysis of factors associated with neurological involvement in primary and secondary Sjögren’s syndrome

From: Clinical features and risk factors of neurological involvement in Sjögren’s syndrome

Independent variables Univariate analysis
OR (95% CI) P value
pSS sSS
Age < 50
Sex (male) 4.55 (1.27, 16.29) 0.020
ESSDAI 1.47 (1.26, 1.72) < 0.001 1.27 (1.05, 1.53) 0.0136
Xerophthalmia, n (%)   3.25 (1.03, 10.23) 0.0440
Low C3 level (< 0.9 g/L) 2.10 (1.06, 4.13) 0.032 3.83 (1.31, 11.24) 0.0143
Low C4 level (< 0.1 g/L) 3.50 (1.02, 12.00) 0.0463
RF positive, n (%) 0.32 (0.12, 0.87) 0.0251
ESR (mm/h) 0.98 (0.96, 1.00) 0.038
Age ≥ 50
Constitutional domain involvement 1.96 (1.08, 3.55) 0.027
ESSDAI 1.52 (1.34, 1.72) < 0.001 1.44 (1.16, 1.80) 0.001
ANA positivity, n (%) 4.50 (1.02, 19.83) 0.047
Cardiac involvement, n (%) 2.28 (1.21, 4.31) 0.010
Xerophthalmia, n (%) 1.82 (1.02, 3.27) 0.044 4.82 (1.56, 14.95) 0.006
Low C3 level (< 0.9 g/L) 1.83 (1.01, 3.30) 0.046
Saliva gland atrophy 0.38 (0.19, 0.74) 0.004
ESR (mm/h) 0.98 (0.96, 1.00) 0.0336
  1. NP neurological, ESSDAI European League Against Rheumatism Sjögren’s syndrome disease activity index, ESSPRI European League Against Rheumatism Sjögren’s syndrome patient reported index, ANA antinuclear antibodies, C3 complement component 3, C4 complement component 4, CRP C-reactive protein, ESR erythrocyte sedimentation rate, LSGB labial salivary gland biopsy, RF rheumatoid factor