Table 4 Enriched biological process GO terms identified for day 6 versus day 1 downregulated genes

GO:0032502

Developmental process

5-HT2, Inx2, CG9634, e, CG17211, Mdr65, sas, fz, Mmp1, dlp, Cht5, uif, cv-2, rpr, Acp65Aa, W, aret, fng, N, Sb, pk, spz5, Cry, vkg, l(3)mbn, Phk-3, scb, Aph-4, Cpr66D, knk, RhoGAP15B, Cpr100A, Cpr49Ac, Pkg21D, ETHR, Cpr49Ah, Cpr49Af, ec, Cpr49Ae, how,, ds, Sema-5c, LanB1, Fas2, dnd, grh, stl, out, TwdlT, Cad74A, esg, Cpr47Ea, miple2, blot, melt, DAAM, Cg25C, fj, Ccp84Ad, drd, Ccp84Ab, bnb, CG31475, spz3, TwdlE, Ccp84Aa, Cpr62Bc, Cpr62Bb, kkv, Cpr73D, Dl, qsm, aay, prc, Cht2, pio, ple, d, dp, CG10348, fw, Pxd, pot, Duox, wdp, Gp150, serp, verm, pbl, Ser, Gasp, Sobp, Tie, mys, scaf, laccase2, Cpr97Ea, Cpr76Bd, Cpr97Eb, Sox14, Cpr50Cb, Cad99C, trn, slow, moody, Ptp10D, aos, Cpr64Aa, Cpr47Ef, CG10641, CG15515, Cpr64Ac, sv, cue, CG10702, Pvr, ken, CG9509, resilin, lz, vn, rdo, CG34375, CG9850, pip, CG17111, Cpr92F, hbs, Cht7, Pu, CG34461, Irk2, Fas3, Cpr11A, CG16857, CG13183, CG13188, conv, CG16884, Ets98B, M6, Sesn, obst-A, Tsp, Cad96Ca, ft, nrv2

GO:0032501

Multicellular organismal process

bmm, Inx2, e, NLaz, Mdr65, CG10226, sas, fz, Mmp1, dlp, Cht5, cv-2, Oamb, aret, W, N, fng, CG34371, pk, Cry, Phk-3, CG30427, scb, Aph-4, knk, CG4221, Cht6, CG10936, Cpr49Ac, CG10407, ec, how, ds, ogre, CG5541, Sema-5c, CG14457, Fas2, grh, esg, miple2, ltd, CG5867, CG8483, Cg25C, fj, drd, Ccp84Ad, bnb, Obp56e, Jhe, kkv, Cpr73D, Dl, aay, CG12344, pio, ple, Cht2, dp, pot, Swim, verm, CG10383, Oatp58Dc, CG42326, pbl, Ser, Tie, mys, Sox14, slow, moody, Ptp10D, CG14259, aos, Obp83g, ImpL2, cue, CG2121, Pvr, CG10702, ken, lz, vn, CG34375, CG15117, pip, GlyP, Cht7, Pu, Fas3, Peritrophin-A, cv, CG2650, Sesn, CG17974, Tsp, Cad96Ca, ft, CG31189, nrv2, CG11852

GO:0044550

Secondary metabolite biosynthetic process

bond, yellow-h, yellow-e, e, yellow-d2, ltd, yellow-c, CG31121

GO:0000003

Reproduction

Ccp84Ad, NLaz, Peritrophin-A, CG2650, Aph-4, CG14259, Obp56e, CG42326, CG14457, CG15117, CG17974, CG31189, CG10407, CG8483, CG5867, CG11852

GO:0007185

Transmembrane receptor protein tyrosine phosphatase signaling pathway

CG13183, CG13188, Gp150

GO:1901071

Glucosamine-containing compound metabolic process

CG13643, CG13183, CG8192, Cda4, CG13188, CG13676, CG14304, Peritrophin-A, serp, obst-B, verm, CG14608, obst-A, Cda5, knk, Cht5, Cht6, kkv, Gasp, CG7714, Cht7, Cht2

GO:0006030

Chitin metabolic process

CG13643, CG13183, CG8192, Cda4, CG13676, CG13188, CG14304, Peritrophin-A, serp, obst-B, verm, CG14608, obst-A, Cda5, knk, Cht5, Cht6, kkv, Gasp, CG7714, Cht7, Cht2

GO:0017144

Drug metabolic process

CG13643, CG8192, Cda4, e, Duox, obst-B, serp, verm, CG14608, Cda5, Cht5, Gasp, Cht7, Pu, CG13183, CG13676, CG13188, CG14304, CG7059, Peritrophin-A, Ahcy89E, obst-A, knk, Cht6, kkv, CG7714, su(r), Cht2, ple

GO:0006022

Aminoglycan metabolic process

CG3038, CG13643, CG13183, CG8192, Cda4, CG13676, CG13188, CG14304, Peritrophin-A, serp, obst-B, verm, CG14608, obst-A, Cda5, knk, Cht5, Cht6, kkv, Gasp, CG7714, Cht7, Cht2

GO:0048856

Anatomical structure development

CG9634, Mdr65, fz, sas, Mmp1, dlp, Cht5, Acp65Aa, aret, W, N, fng, Sb, spz5, Cry, vkg, l(3)mbn, Phk-3, scb, Aph-4, Cpr66D, knk, Cpr100A, Pkg21D, Cpr49Ac, Cpr49Ah, Cpr49Af, Cpr49Ae, how, Sema-5c, LanB1, Fas2, grh, TwdlT, stl, out, esg, Cpr47Ea, melt, DAAM, Cg25C, drd, Ccp84Ad, Ccp84Ab, bnb, spz3, TwdlE, Ccp84Aa, Cpr62Bc, Cpr62Bb, kkv, Cpr73D, Dl, aay, prc, pio, Cht2, ple, d, dp, CG10348, fw, pot, Duox, wdp, Gp150, serp, verm, pbl, Ser, Gasp, Sobp, Tie, mys, laccase2, Cpr97Ea, Cpr76Bd, Sox14, Cpr97Eb, Cpr50Cb, slow, moody, Ptp10D, Cpr64Aa, aos, Cpr47Ef, Cpr64Ac, CG15515, CG10641, sv, cue, Pvr, CG10702, ken, CG9509, resilin, lz, vn, CG34375, rdo, CG9850, pip, Cpr92F, Cht7, Pu, Irk2, CG34461, CG16857, Cpr11A, Fas3, conv, CG16884, M6, obst-A, Sesn, Tsp, Cad96Ca, ft, nrv2

GO:0009611

Response to wounding

Cht5, kkv, Spn28Dc, Cad96Ca, scb, Cht7, CG11089, Mmp1, lz, Cht2, ple

GO:0006032

Chitin catabolic process

Cht6, Cht5, Cda4, serp, verm, Cht7, Cda5, Cht2

GO:0042737

Drug catabolic process

Cht6, Cht5, Cda4, serp, verm, su(r), Cht7, Cda5, Cht2

GO:0022404

Molting cycle process

Cht6, Cht5, dp, pot, e, Cht7, Cht2, pio

GO:0009886

Post-embryonic animal morphogenesis

d, dp, how, fw, pot, ds, Duox, fz, Mmp1, dlp, vn, Ser, Fas2, cv-2, rpr, scaf, mys, Cg25C, W, fng, N, fj, pk, trn, aos, RhoGAP15B, Pvr, Dl, ft, pio

GO:0046667

Compound eye retinal cell programmed cell death

Dl, W, N, ec

GO:0060541

Respiratory system development

dp, conv, serp, Ptp10D, verm, Mmp1, knk, kkv, grh, esg, Dl, nrv2, DAAM, W, N, pio

GO:0007475

Apposition of dorsal and ventral imaginal disc-derived wing surfaces

dp, how, pot, Dl, mys, pio

GO:0048731

System development

dp, ken, serp, verm, Mmp1, pbl, vn, grh, esg, mys, melt, DAAM, W, N, spz5, conv, spz3, Aph-4, Ptp10D, knk, kkv, Dl, aay, nrv2, pio

GO:0008362

Chitin-based embryonic cuticle biosynthetic process

dp, kkv, pot, Gasp, grh, obst-A, knk, Cht2, pio

GO:0042335

Cuticle development

dp, pot, Duox, resilin, Cht5, Gasp, grh, TwdlT, Cpr92F, Cpr47Ea, Acp65Aa, Cht7, Pu, laccase2, Cpr97Ea, Ccp84Ad, drd, CG34461, Cpr76Bd, Cpr97Eb, Cpr11A, Ccp84Ab, Cpr50Cb, l(3)mbn, TwdlE, Cpr64Aa, Cpr66D, Cpr62Bc, Ccp84Aa, Cpr47Ef, obst-A, Cpr64Ac, CG15515, knk, Cpr62Bb, kkv, Cpr100A, Cpr73D, Cpr49Ac, Cpr49Ah, Cpr49Af, Cpr49Ae, Cht2, pio

GO:0040005

Chitin-based cuticle attachment to epithelium

dp, pot, pio

GO:0016339

Calcium-dependent cell–cell adhesion via plasma membrane cell adhesion molecules

ds, Cad99C, Cad87A, Cad74A, Cad96Ca, ft, mys, scb

GO:0044331

Cell–cell adhesion mediated by cadherin

ds, Cad99C, Cad87A, Cad74A, ft

GO:0007156

Homophilic cell adhesion via plasma membrane adhesion molecules

Fas2, CG16857, Fas3, fw, ds, Cad99C, Cad96Ca, Cad87A, Cad74A, ft, fz, hbs

GO:0035112

Genitalia morphogenesis

Fas2, Pvr, rpr, scaf, mys, N

GO:0007157

Heterophilic cell–cell adhesion via plasma membrane cell adhesion molecules

Fas3, ds, ft, scb, mys, hbs, N

GO:0042067

Establishment of ommatidial planar polarity

fj, d, pk, fw, ds, Dl, ft, fz, hbs, aos, N

GO:0090066

Regulation of anatomical structure size

fj, dp, ds, Cad99C, conv, slow, fz, serp, verm, Mmp1, knk, obst-A, pbl, Fas2, kkv, grh, Gasp, Cad96Ca, ft, nrv2, DAAM, aret

GO:0035150

Regulation of tube size

fj, ds, conv, fz, serp, verm, Mmp1, knk, obst-A, Fas2, kkv, Gasp, grh, ft, nrv2

GO:0035159

Regulation of tube length, open tracheal system

fj, ds, conv, serp, fz, verm, Mmp1, knk, Fas2, kkv, grh, ft, nrv2

GO:0035152

Regulation of tube architecture, open tracheal system

fj, ds, conv, serp, fz, verm, Mmp1, obst-A, knk, Fas2, kkv, uif, Gasp, grh, ft, mys, nrv2, DAAM

GO:0098742

Cell–cell adhesion via plasma-membrane adhesion molecules

fw, CG16857, Fas3, ds, Cad99C, fz, scb, Fas2, Cad96Ca, Cad74A, Cad87A, ft, mys, hbs, N

GO:0098609

Cell–cell adhesion

fw, Fas3, CG16857, ds, Cad99C, fz, scb, Fas2, Cad87A, Cad74A, Cad96Ca, ft, mys, hbs, N

GO:0007155

Cell adhesion

fw, how, ds, Swim, fz, Mmp1, sprt, LanB1, Fas2, Cad74A, mys, hbs, N, Fas3, CG16857, zye, Cad99C, trn, scb, CG15080, ImpL2, Tsp, Cad87A, Cad96Ca, ft, Dl, nrv2, prc

GO:0090099

Negative regulation of decapentaplegic signaling pathway

Irk2, Fs, scaf

GO:0006031

Chitin biosynthetic process

kkv, CG13183, CG13188, knk

GO:0060439

Trachea morphogenesis

kkv, CG13183, CG13188, verm

GO:0048085

Adult chitin-containing cuticle pigmentation

kkv, e, Duox, CG10625, CG9134, ple

GO:0001838

Embryonic epithelial tube formation

kkv, Mmp1, knk

GO:0048585

Negative regulation of response to stimulus

nimA, slif, wdp, fz, dlp, pbl, l(2)34Fc, Fas2, Ser, uif, Coop, Tie, scaf, GlyP, fng, N, Irk2, pk, Spn28Dc, aos, Sesn, ImpL2, CG4096, Fs, Cad96Ca, CG10702, Pvr, ft

GO:0023057

Negative regulation of signaling

nimA, wdp, fz, dlp, pbl, Fas2, Ser, uif, Coop, Tie, scaf, fng, N, Irk2, pk, CG8317, aos, Sesn, ImpL2, CG4096, Fs, Cad96Ca, CG10702, Pvr, ft, egr, CG12344

GO:0048067

Cuticle pigmentation

Pu, kkv, yellow-h, yellow-e, e, Duox, yellow-d2, CG10625, CG9134, yellow-c, ple

GO:0043473

Pigmentation

Pu, kkv, yellow-h, yellow-e, e, Duox, yellow-d2, ltd, CG10625, CG9134, yellow-c, ple

GO:0046148

Pigment biosynthetic process

Pu, se, santa-maria, yellow-h, yellow-e, e, yellow-d2, ltd, yellow-c, DhpD, CG31121

GO:0007508

Larval heart development

scb, mys, prc

GO:0035001

Dorsal trunk growth, open tracheal system

scb, mys, verm, Mmp1

GO:0035161

Imaginal disc lineage restriction

Ser, Dl, fng, N

GO:0007451

Dorsal/ventral lineage restriction, imaginal disc

Ser, Dl, N, fng

GO:0035170

Lymph gland crystal cell differentiation

Ser, lz, N

GO:0042438

Melanin biosynthetic process

yellow-h, yellow-e, e, yellow-d2, yellow-c