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Fig. 6 | BMC Neuroscience

Fig. 6

From: Neurovascular dysfunction in vascular dementia, Alzheimer’s and atherosclerosis

Fig. 6

Adapted from [21, 108]

Summary of vascular pathologies in CVD, stroke and dementia. Vascular dysfunction pathway for stroke, vascular dementia and AD; AD-specific factors in red text (incorporating the 2-hit hypothesis for AD—hit 1 being at vessel damage and hit-2 being Aβ increase). CVD can directly cause cerebral vessel damage to cause either strokes and/or vascular dementia, in addition to initiating AD pathology if certain risk factors are present.

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