Skip to main content
Fig. 1 | BMC Neuroscience

Fig. 1

From: Biaryl scaffold-focused virtual screening for anti-aggregatory and neuroprotective effects in Alzheimer’s disease

Fig. 1

Pathogenesis of Alzheimer disease (AD) and therapeutic intervention are shown. (1) Acetylcholine (ACh) inhibitor activation leads towards ACH deficit in effected brain and drugs that inhibits acetylcholinesterase (Donepezil). (2) Aβ generation and aggregation and its sites for therapeutic intervention. All the drugs currently used in this regard is in clinical trial phase. (3) Oxidative stress; ROS can aggravate and trigger AD, Antioxidant maybe helpful. (4) Glutamatergic dysfunction and excitotoxicity play role in pathogenesis of AD. NMDA receptor antagonist (Memantine) are the treatment option

Back to article page