Skip to main content
Fig. 3 | BMC Neuroscience

Fig. 3

From: Dyskinesia and brain-derived neurotrophic factor levels after long-term levodopa and nicotinic receptor agonist treatments in female mice with near-total unilateral dopaminergic denervation

Fig. 3

No effect on levodopa-induced dyskinesia by chronic treatment with nicotinic receptor agonists. Mice were lesioned unilaterally with 6-OHDA, and dyskinesia was pre-induced by 2 weeks of levodopa treatment (6 mg/kg s.c.). a The α7 receptor partial agonist AZD0328 was administered s.c. 30 min before levodopa for 1 week per dose (5 days per week), and dyskinesia severity was assessed from video recordings captured on the fifth day. No statistically significant differences in total dyskinesia severity between treatment groups were found. b After a 1-week washout, chronic levodopa treatment (6 mg/kg) was continued and nicotine treatment in drinking water (up to 300 µg/ml) was initiated. Dyskinesia severity was assessed from weekly video recordings. Nicotine treatment did not reduce but transiently exacerbated dyskinesia severity, with a statistically significant effect on axial dyskinesia (two-way repeated measures ANOVA, treatment × time, P < 0.05). Values represent the mean ± SEM of 6 mice

Back to article page