Fig. 2
Correlation analysis of lesion distance and change in gene expression. The location of axotomy relative to the neuronal cell body is an important determinant for the post-injury responses exhibited in terms of changes in gene expression. This relationship was examined using a correlation analysis comparing the TPS neurons response to a T10 injury, to the response of LDPT neurons receiving an injury at T10 (a), and the response of LDPT neurons receiving an injury at T2 (b). When changes in gene expression were compared between LDPT neurons receiving a distant axotomy (T10) and the TPS neurons close to the injury site, the correlation was r = 0.38 (a). However, when the LDPT neurons near a local axotomy (T2) were compared to the TPS neurons, a correlation of r = 0.803 was observed (b)