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Fig. 6 | BMC Neuroscience

Fig. 6

From: Involvement of brain-derived neurotrophic factor (BDNF) in chronic intermittent stress-induced enhanced mechanical allodynia in a rat model of burn pain

Fig. 6

Effects of chronic stress and thermal injury on PFC and hypothalamic BDNF mRNA and protein level. Although the combined effects of chronic stress and thermal injury elevated ipsilateral and contralateral PFC BDNF mRNA expression, significant differences between groups (NS + I vs. S + I) was observed in the contralateral PFC (a). Ipsilateral and contralateral hypothalamus BDNF mRNA expression was not significantly different between experimental groups (c). BDNF protein level in the ipsilateral and contralateral PFC and hypothalamus are shown by Simple Western blot representative image (above quantification graphs of b, d). BDNF protein level was comparable among experimental groups in ipsilateral and contralateral PFC (b). BDNF protein was significantly decreased in the ipsilateral hypothalamus of S + I group in comparison to NS and NS + I groups (d). NS non-stress, S stress; I injury. n = 5/group. * = P < 0.05, **P < 0.01

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