Fig. 3
From: Gastrodin protects dopaminergic neurons via insulin-like pathway in a Parkinson’s disease model
Gastrodin rescues chemotaxis behavior by DAF-2/DAF-16. a In the two PD models, the chemotaxis behavior of worms was increased after treatment with gastrodin. b Gastrodin obviously increased chemotaxis behavior in two PD models. c The mutant daf-16(mu86) shows decreased chemotaxis compared to wild type, and treatment of the mutant with gastrodin did not rescue the behavior. d Gastrodin increased the nuclear accumulation of DAF-16::GFP. The scale bar and magnification of left panel is 50 μm, 200. e Quantification of DAF-16::GFP nuclear accumulation in no gastrodin and gastrodin conditions. f daf-2 mutation exhibited an increased chemotaxis index, and the double-mutants daf-2;daf-16 restored the level to that of wild type animals. The statistical differences were analyzed using t-test method, ns P ≥ 0.05; *P < 0.05; **P < 0.01; ***P < 0.001