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Table 1 Use of intravenous fluids, mean arterial pressure, and changes in laboratory values

From: Impact of inflammation on brain subcellular energetics in anesthetized rats

Variable

Isoflurane groups

Propofol groups

Sham (isoflurane)

CLP (isoflurane)

Sham vs. CLP

Sham (propofol)

CLP (propofol)

Sham vs. CLP

Mean

SD

Mean

SD

p value

Mean

SD

Mean

SD

p value

Fluids given (mL/kg)

6.91

2.11

13.21

3.32

0.004

11.89

6.21

20.85

5.71

0.001

MAP (start)

95.86

8.69

95.92

13.17

0.507

90.71

19.37

75.44

16.34

0.049

MAP (end)

102.38

8.71

77.06

23.08

0.001

82.35

12.78

67.23

16.61

0.020

MAP change

6.53

5.51

− 18.85

25.51

0.002

− 8.36

21.98

− 8.22

18.56

0.987

Lactate (start)

2.68

0.82

1.85

0.64

0.007

1.11

0.49

1.06

0.55

0.789

Lactate (end)

1.88

0.56

2.48

1.19

0.125

0.85

0.30

0.85

0.38

0.972

Lactate (change)

− 0.80

0.72

0.64

1.48

0.006

− 0.26

0.60

− 0.21

0.69

0.843

Lactate (clearance)

27.58

22.71

− 50.88

84.40

0.005

− 1.20

77.69

− 3.72

86.06

0.931

BE (start)

4.92

4.14

4.75

4.14

0.922

7.42

2.81

6.50

2.11

0.197

BE (end)

− 3.83

4.11

− 7.58

4.01

0.034

3.42

3.23

− 1.42

3.90

0.003

BE change

− 8.75

2.99

− 12.33

5.96

0.076

− 4.00

4.69

− 7.92

2.94

0.023

Glucose (start)

379.33

85.57

396.75

86.98

0.626

375.75

50.83

373.17

92.47

0.665

Glucose (end)

200.33

43.81

159.42

85.93

0.156

136.17

25.21

113.42

22.50

0.019

Glucose change

− 179.00

94.24

− 237.33

108.88

0.174

− 239.58

66.84

− 259.75

88.57

0.686

Anesth. dose

1.50

0.00

1.40

0.13

0.016

406.67

167.46

327.08

126.39

0.202

Cr (start)

0.28

0.05

0.30

0.10

0.421

0.25

0.10

0.25

0.08

0.801

Cr (end)

0.39

0.48

0.57

0.52

0.088

0.79

0.34

0.91

0.40

0.450

Cr (change)

0.12

0.47

0.27

0.50

0.128

0.54

0.35

0.66

0.41

0.459

Cr (clearance)

− 38.89

155.59

− 94.86

183.41

0.121

− 242.36

160.08

− 290.28

200.56

0.524

BUN (start)

20.58

2.64

22.17

2.55

0.336

20.00

3.81

19.83

3.33

0.861

BUN (end)

39.75

17.49

48.25

17.28

0.244

34.08

6.26

40.33

10.71

0.026

BUN (change)

19.17

16.92

26.08

16.43

0.082

14.08

5.05

20.50

11.12

0.008

IL-6 (base)

145.00

50.79

146.05

33.92

0.957

67.12

22.87

51.04

24.82

0.104

IL-6 (8 h)

108.85

36.72

186.77

94.75

0.026

71.18

24.61

103.49

34.38

0.027

IL-6 difference

− 36.14

60.25

40.72

102.63

0.056

4.06

37.77

52.44

38.03

0.011

TNF-a (base)

11.32

22.62

15.90

19.74

0.635

18.27

85.50

32.29

200.92

0.733

TNF-a (8 h)

25.26

21.85

66.09

45.97

0.021

− 17.79

25.99

305.22

205.95

0.000

TNF-a difference

13.94

34.75

50.19

47.14

0.066

− 36.06

95.83

272.93

269.44

0.003

IL-1B (base)

98.90

74.58

114.38

38.48

0.567

323.29

106.47

354.79

75.78

0.456

IL-1B (8 h)

101.73

58.06

153.34

41.77

0.035

309.60

95.37

625.25

398.89

0.026

IL-1B difference

2.84

40.46

38.96

41.35

0.088

− 13.69

90.66

270.46

428.46

0.055

  1. italic denotes a statistically significant difference between animals exposed to sepsis and controls
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BMC Neuroscience

ISSN: 1471-2202

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