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Fig. 1 | BMC Neuroscience

Fig. 1

From: Post-surgical inhibition of phosphatidylinositol 3-kinase attenuates the plantar incision-induced postoperative pain behavior via spinal Akt activation in male mice

Fig. 1

PI3K inhibitor attenuated mechanical allodynia, thermal hyperalgesia, and cumulative pain scores induced by plantar incision in male mice. Wortmannin (0.016, 0.08, and 0.4 μg), LY294002 (0.2, 1, and 5 μg) or DMSO was intrathecally injected at 90 min after plantar incision. Paw withdrawal threshold (PWT) to mechanical stimuli, paw withdrawal latency (PWL) to radiant heat, and cumulative pain scores (CPS) were recorded at 0.5, 2, 4, 8, 12, 24, and 48 h after plantar incision. Post-surgical inhibition of PI3K with various doses of wortmannin (a–c) or LY294002 (d–f) attenuated the reduction of PWT (a, d) and PWL (b, e), or the induction of CPS (c, f) induced by plantar incision in a dose-dependent manner. ###P < 0.001, compared with Sham-DMSO group; *P < 0.05, **P < 0.01, ***P < 0.001, compared with incision-DMSO group; &P < 0.05, &&P < 0.01, &&&P < 0.001, compared with Incision-Wort 0.08 group or Incision-LY 1 group (two-way repeated measure ANOVA followed by Bonferroni’s post-test; n = 10 mice in each group). Data were presented as mean ± SEM. Wort wortmannin, LY LY294002

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BMC Neuroscience

ISSN: 1471-2202

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