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Fig. 3 | BMC Neuroscience

Fig. 3

From: Post-surgical inhibition of phosphatidylinositol 3-kinase attenuates the plantar incision-induced postoperative pain behavior via spinal Akt activation in male mice

Fig. 3

Post-surgical inhibition of PI3K attenuated the spinal Fos protein expression induced by plantar incision in male mice. PI3K inhibitor wortmannin (0.4 μg) or LY294002 (5 μg) was intrathecally injected 45 min after plantar incision. Spinal Fos protein expression was assayed at 2 h after plantar incision. a Representative immunohistochemical staining of Fos expression in the spinal cord. b Quantitative data of Fos expression in the spinal cord. ###P < 0.001, compared with Sham-DMSO group; ***P < 0.001, compared with Incision-DMSO group (one-way ANOVA, followed by Bonferroni’s multiple comparison test; n = 6 mice in each group). Data are presented as mean ± SEM. Scale bar = 200 μm

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BMC Neuroscience

ISSN: 1471-2202

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