Fig. 2

Representative, high magnification, images of S-opsin⁺ cones and M/L-opsin⁺ cones in retinal wholemounts of Rd1 mice from postnatal day (P) 14 to P300. Double labeling immunofluorescence was performed using antibodies directed against S-opsin (red) and M/L-opsin (green). Outer segments of both cone types label intensely at P14. By P45, large numbers of outer segments had degenerated, allowing better visualisation of cone cell bodies. S-P superior-peripheral retina, S-C superior-central retina, I-C inferior-central retina, I-P inferior-peripheral retina. Scale bar: 100 μm