Fig. 1

a Our method uses a per-pixel generative model with non-local spatially correlated coefficients. b Temporal DL finds subtle features in the Neurofinder dataset. For example, shown here is an apical dendrite (blue) significantly overlapping with a soma (green) was isolated. Manually labeled soma (yellow) and Suite2p (red) do not account for the apical, resulting in contaminated time-traces. c Applications to dendritic data extracts both dendrite and spine activity (bottom), as seen by the spatial maps where each component is colored differently (top). d In widefield imaging, the reconstructed movie recapitulates the behaviorally-triggered dynamics [6], demonstrating that it captures the scientifically-relevant activity