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Table 3 The fold change of 27 different genes between different groups 4.5 h-post MCAO (n = 4)

From: Lipopolysaccharide worsens the prognosis of experimental cerebral ischemia via interferon gamma-induced protein 10 recruit in the acute stage

NO

Symbol

Gene name

SL/S

M/S

ML/S

ML/SL

ML/M

Fold Change

P value

Fold change

P value

Fold change

P value

Fold change

P value

Fold change

P value

1

Ccl2

Chemokine (C–C motif) ligand 2

1.16

0.624153

41.26

0.000511

37.94

0.000007

32.58

0.000007

− 1.09

0.533847

2

Csf3

Colony stimulating factor 3 (granulocyte)

1.36

0.424448

31.67

0.001058

49.21

0.003854

36.21

0.004366

2.61

0.277418

3

Tnf

Tumor necrosis factor (TNF superfamily, member 2)

1.42

0.397124

16.13

0.000025

16.46

0.000231

11.62

0.000251

1.02

0.835561

4

Il1b

Interleukin 1 beta

2.12

0.162953

13.36

0.004208

17.92

0.019435

8.45

0.028306

1.34

0.391086

5

Il6

Interleukin 6

1.28

0.400687

10.19

0.001754

11.44

0.007411

8.96

0.008197

1.12

0.623980

6

Fos

FBJ osteosarcoma oncogene

1.06

0.710817

8.04

0.002002

6.30

0.000222

5.93

0.000227

− 1.28

0.260185

7

Cd14

CD14 molecule

1.61

0.03763

7.14

0.005989

7.63

0.020957

4.73

0.029492

1.07

0.724771

8

Cxcl10

Chemokine (C-X-C motif) ligand 10

3.75

0.145277

6.98

0.002887

11.41

0.000000

3.04

0.010848

1.64

0.019928

9

Il1a

Interleukin 1 alpha

− 2.19

0.008363

6.27

0.000078

8.44

0.001116

18.50

0.000785

1.35

0.145179

10

Csf2

Colony stimulating factor 2 (granulocyte–macrophage)

− 2.06

0.25762

5.72

0.009292

4.77

0.056506

9.82

0.037527

− 1.20

0.920961

11

Clec4e

C-type lectin domain family 4, member e

2.16

0.156541

5.14

0.026359

5.76

0.000262

2.66

0.008226

1.12

0.964266

12

Ptgs2

Prostaglandin-endoperoxide synthase 2

1.06

0.629061

3.66

0.016385

3.32

0.016856

3.13

0.019496

− 1.10

0.719302

13

Rel

V-rel avian reticuloendotheliosis viral oncogene homolog

1.00

0.97117

2.92

0.000142

2.52

0.000300

2.51

0.000291

− 1.16

0.234818

14

Nfkb2

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100

1.22

0.032549

2.61

0.000035

1.72

0.001922

1.41

0.015419

− 1.51

0.004386

15

Tnfrsf1a

Tumor necrosis factor receptor superfamily, member 1a

1.20

0.163441

2.60

0.001290

2.31

0.000009

1.93

0.000025

− 1.13

0.270250

16

Irak2

Interleukin-1 receptor-associated kinase 2

1.25

0.528495

2.13

0.094605

2.66

0.019540

2.12

0.099720

1.25

0.502009

17

Irf1

Interferon regulatory factor 1

1.68

0.004013

2.57

0.001319

3.16

0.103964

1.88

0.205620

1.23

0.464775

18

Hspa1a

Heat shock 70kD protein 1A

1.03

0.831752

2.54

0.034229

2.08

0.029451

2.01

0.001303

− 1.22

0.266003

19

Myd88

Myeloid differentiation primary response gene 88

1.42

0.025778

2.46

0.001309

2.13

0.000289

1.49

0.000757

− 1.16

0.192018

20

Cd86

CD86 molecule

− 1.25

0.164326

2.42

0.003734

2.20

0.000224

2.74

0.000050

− 1.10

0.441172

21

Jun

Jun oncogene

1.16

0.391817

2.40

0.000204

1.98

0.006514

1.70

0.008321

− 1.21

0.130578

22

Il2

Interleukin 2

− 1.37

0.247581

1.78

0.246109

1.57

0.566071

2.15

0.015648

− 1.13

0.508809

23

Map2k3

Mitogen activated protein kinase kinase 3

1.05

0.670387

2.13

0.000237

1.89

0.000129

1.80

0.001076

− 1.12

0.112187

24

Il6r

Interleukin 6 receptor

1.27

0.145584

2.10

0.002435

1.88

0.007729

1.48

0.010756

− 1.12

0.392462

25

Lta

Lymphotoxin alpha (TNF superfamily, member 1)

1.25

0.264619

2.01

0.033772

1.16

0.520200

-1.07

0.993379

− 1.73

0.172841

26

Nfkbia

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

1.26

0.024038

2.00

0.000121

2.02

0.008320

1.60

0.021173

1.01

0.865093

27

Tlr1

Toll-like receptor 1

1.13

0.220799

1.87

0.031940

2.34

0.018029

2.08

0.024212

1.25

0.400292

  1. S stands for Sham group, SL stands for Sham + LPS group; M stands for MCAO group, and ML stands for MCAO + LPS group