Fig. 3

Four major clusters correspondent to each quadrant elucidated by PCA based on 33 reference genes expression profiles (Table 1). Quadrants are denoted with corresponding labels (D1/D2/DA depleted) along with marker gene names. Inserted is a scheme of antagonistic clusters: the arrows depict alternative states of D1 MSN, and D2/DA-depleted states. Blue dotted arrow indicates antagonistic gradient of dopamine and glutamate according to the corresponding receptors distribution. Inserted (small figure) is a scheme of antagonistic clusters: the arrows depict alternative states of D1 MSN, and D2/DA-depleted states. Cluster—specific marker genes are outlined with bold type. Denotations: C1, C2, C3—control; A1, A2, A3—aggressive mice; L1, L2, L3—losers, defeated mice