Fig. 6

Two types of MSNs, D2 (a) and D1 (b) are represented by the same cAMP-centered gene cascades. Colored are correlated gene clusters observed in our study (3 clusters; Fig. 1). a Stable D2-A2A-Golf-Gi/o complex features preferential inhibition of AC5→cAMP synthesis upon DA (dopamine) signal, though stimulants can invoke it [35, 36]. Genes encoding proteins shaded red are coordinately regulated in D2 neurons as observed in our RNA-Seq data (Fig. 1). Genes encoding uncolored proteins are absent in the D2 cluster (Fig. 1), implying they may be present with minor expression ranges and are not involved in coordinated variation. b Oscillating passive-active cascades in D1 neurons. Genes encoding proteins of the same color manifest correlated clusters in our data presented in Fig. 2. Blue (D1 passive state) vs Red (D1 active state) clusters are antagonistic ones according to AHC and PCA analyses (Figs. 1 and  3). Genes encoding uncolored proteins are absent in the D1 cluster (Fig. 1), implying they may be present with minor expression ranges and are not involved in coordinated variation