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Table 2 Coefficient of variation (CV) for inter-scanner volumetric measurements among GE, Siemens and Philips

From: Inter-scanner reproducibility of brain volumetry: influence of automated brain segmentation software

 

Coefficient of variation

p-value

FreeSurfer

FSL-FIRST

AccuBrain

FreeSurfer vs. FSL-FIRST

AccuBrain vs. FreeSurfer

AccuBrain vs. FSL-FIRST

WM

8.117

N.A.

1.348

N.A.

0.005

N.A.

GM

6.946

N.A.

1.927

N.A.

< 0.001

N.A.

Hippocampus L

7.706

9.600

8.800

0.151

0.978

0.679

Hippocampus R

8.459

10.57

8.144

0.489

0.561

0.064

Amygdala L

10.35

17.15

3.768

0.010

< 0.001

< 0.001

Amygdala R

10.23

20.98

3.557

0.004

0.002

< 0.001

Lateral ventricle L

9.123

N.A.

2.547

N.A.

0.001

N.A.

Lateral ventricle R

8.631

N.A.

2.892

N.A.

0.008

N.A.

VentralDC L

9.809

N.A.

4.298

N.A.

0.018

N.A.

VentralDC R

9.350

N.A.

3.685

N.A.

0.022

N.A.

Thalamus L

8.632

8.919

1.635

0.679

< 0.001

< 0.001

Thalamus R

8.440

9.739

1.811

0.524

< 0.001

< 0.001

Caudate L

9.597

12.91

2.750

0.083

< 0.001

< 0.001

Caudate R

9.331

14.11

2.314

0.073

0.001

< 0.001

Putamen L

10.77

11.61

2.755

0.720

< 0.001

< 0.001

Putamen R

9.793

11.64

2.471

0.330

0.001

< 0.001

Pallidum L

12.29

7.245

4.025

0.018

< 0.001

0.007

Pallidum R

11.77

9.306

2.316

0.389

0.001

< 0.001

Accumbens L

11.72

13.93

4.859

0.679

< 0.001

0.001

Accumbens R

10.43

18.75

5.014

0.015

0.002

< 0.001

Average

9.577

12.60a

3.546

0.041

0.001

< 0.001

  1. The mean values of region-specific CV (i.e. inter-scanner variability in brain volumetry of the three scanners) of the examined 15 subjects are displayed for each ABS tool, and the associated pairwise comparison results (i.e. p values) of the coefficients of variation among the ABS tools are also provided
  2. GM gray matter, N.A. not available, WM white matter, VentralDC ventral diencephalon, L Left, R Right
  3. The average CV of FSL-FIRST for different brain substructures is the mean over the structures available for quantification in FSL-FIRST (i.e. hippocampus, amygdala, thalamus, caudate, putamen, pallidum and accumbens)