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Table 1 Sensitivity and specificity of five anti-TDP FTD scFvs based on reactivity with FTD-TDP (n = 12), FTD-tau (n = 12) and control sera (n = 8)

From: Isolation and characterization of antibody fragments selective for human FTD brain derived TDP-43 variants

scFv

FTD-TDP

FTD-Tau

Total

Sensitivity (%)

Specificity (%)

AUC

Sensitivity (%)

Specificity (%)

AUC

Sensitivity (%)

Specificity (%)

AUC

FTD-TDP1

91.66

100

0.99

75

75

0.85

75

87.5

0.92

FTD-TDP2

75

100

0.87

75

100

0.82

75

100

0.84

FTD-TDP3

100

87.5

0.99

91.66

87.5

0.96

95.83

100

0.99

FTD-TDP4

100

83.3

0.97

75

75

0.79

75

87.5

0.88

FTD-TDP5

100

100

1

100

100

1

100

100

1

  1. Sensitivity and specificity were calculated for FTD-TDP, FTD-tau and both FTD subtypes–AUC values greater than 0.95 are highlighted