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Fig. 3 | BMC Neuroscience

Fig. 3

From: Does conserved domain SOD1 mutation has any role in ALS severity and therapeutic outcome?

Fig. 3

SOD1 variants fall in conserved domain can alter the action of regulatory sequences by distorting the protein structure. a Significant changes in Cβ between 2b + 3a and 4 RegulomeDB score. (b, c) Gibb’s free energy and entropy alterations among RegulomeBD groups. p-value computed by employing ANOVA. Bar is representing SEM; P value * < 0.05, ** < 0.001, *** < 0.0001. RegulomeDB 2b + 3a (n = 11); RegulomeDB 4 (n = 46); RegulomeDB 5 (n = 9)

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