Fig. 3From: Does conserved domain SOD1 mutation has any role in ALS severity and therapeutic outcome?SOD1 variants fall in conserved domain can alter the action of regulatory sequences by distorting the protein structure. a Significant changes in Cβ between 2b + 3a and 4 RegulomeDB score. (b, c) Gibb’s free energy and entropy alterations among RegulomeBD groups. p-value computed by employing ANOVA. Bar is representing SEM; P value * < 0.05, ** < 0.001, *** < 0.0001. RegulomeDB 2b + 3a (n = 11); RegulomeDB 4 (n = 46); RegulomeDB 5 (n = 9)Back to article page