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Table 4 Tabular representation of PROVEAN, SIFT and PolyPhen-2 scores along with Gibb’s free energy and entropy values for studied variants which fall in variable domain of SOD1 protein

From: Does conserved domain SOD1 mutation has any role in ALS severity and therapeutic outcome?

Mutation

DDG (Kcal/mol)

Stability

ΔΔG ENCoM kcal/mol

Stability

ΔΔSVib ENCoM (kcal.mol−1.K−1)

Mol flex

Provean

Eff.

RI

Eff.

SIFT

Eff.

Pphen2

Eff.

Reg.

E101G

−1.46

Dec

−0.381

Destab

0.476

Inc

−3.072

Del

2

Dis

0.18

Tol

0.439

Ben

4

L145S

−2.75

Dec

−0.523

Destab

0.654

Inc

−4.146

Del

6

Dis

0.05

Tol

0.999

Pro d

4

E22K

−1.14

Dec

0.084

Destab

−0.104

Dec

−2.154

Neu

2

Neu

0.32

Tol

0.9

POS D

4

D97N

−2.41

Dec

0.108

Destab

−0.135

Dec

−0.31

Neu

5

Neu

0.44

Tol

0

Ben

4

L145F

−1.13

Dec

0.382

Destab

−0.478

Dec

−2.951

Del

8

Dis

0.06

Tol

0.999

Pro d

4

G74R

−0.71

Dec

1.48

Stab

−1.85

Dec

−5.79

Del

4

Dis

0.06

Tol

1

Pro d

 

D91A

−2.46

Dec

−0.148

Destab

0.185

Inc

−2.437

Neu

6

Dis

0.13

Tol

0

Ben

3a

N20S

−0.39

Dec

−0.031

Destab

0.038

Inc

−1.081

Neu

9

Neu

0.4

Tol

0.003

Ben

4