From: Does conserved domain SOD1 mutation has any role in ALS severity and therapeutic outcome?
Parameter | Component(s) | Frequency |
---|---|---|
Domain location | Variable | 8 |
Average | 11 | |
Conserve | 49 | |
PROVEAN phenotype | Deleterious | 62 |
Neutral | 6 | |
SIFT phenotype | Affect protein | 52 |
Tolerant | 16 | |
DDG iMutant stability | Decrease | 63 |
Increase | 5 | |
EcoDDG stability | Destabilize | 60 |
Stabilize | 8 | |
Eco entropy dynamut Flexibility | Decrease | 38 |
Increase | 30 | |
HumDiv phenotype | Benign | 7 |
Possibly damaging | 8 | |
Probably damaging | 53 | |
RegulomeDB | 2b + 3a | 11 |
4 | 46 | |
5 | 9 |