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Fig. 3 | BMC Neuroscience

Fig. 3

From: SCN11A gene deletion causes sensorineural hearing loss by impairing the ribbon synapses and auditory nerves

Fig. 3

Audiological characterization of Nav1.9−/− mice. a Mean ABR thresholds of six wild-type, four heterozygous and seven homozygous versus sound frequency, **p = 0.002, **p = 0.001 at 12 kHz compared with homozygous, *p = 0.01, ***p = 0.000 at 16 kHz compared with homozygous by one-way ANOVA with Bonferroni’s post-hoc test. b Example of ABR waveforms at 16 kHz in one ear of a wild-type superimposed on an example of ABR waveforms in one ear of Nav1.9−/− mice. c ABR thresholds of WT and homozygous mice of postnatal day 21 to 60 at 8 kHz. p = 0.807 at P21; p = 0.932 at P30; p = 0.504 with independent samples t test; n.s.: not significant. d ABR threshold of WT and homozygous mice of postnatal day 21 to 60 at 16 kHz. *p = 0.016, **p = 0.006, ***p = 0.000 with Mann–Whitney test. Data are expressed as mean ± s.d

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