Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism

BMC Neuroscience

Table 1 Summary of behavioral tests, oxytocin concentrations and effects of oxytocin in Chd8^+/∆SL mice

Parameter	Test	Phenotype	Oxytocin effect
Locomotion	Open field	Normal
Social Avoidance	Social avoidance test	Normal
Anxiety	Social avoidance test Elevated plus maze Light dark box Reverse light dark box	Anxious	Corrected in males in light dark box
Sociability	3-chamber box	Normal
Social preference	3-chamber box	Absence in males Increased to novelty in females	Corrected
Depression	Sucrose preference Tail suspension test	Depressive phenotype in females
Oxytocin concentration		Decreased in males

ISSN: 1471-2202