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Fig. 11 | BMC Neuroscience

Fig. 11

From: MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease

Fig. 11

Testing social interaction and social memory of male mice using the three-chamber test. Male wild type, 5xFAD, 5xFAD/MMP9KO and MMP9KO mice were tested for A, B social interaction (one mouse vs empty cage) and C, D social memory (novel mouse vs familiar mouse) in the three-chamber test. Time spent in A, C the whole chamber containing the mouse/empty cage and B, D the proximal zone surrounding the cages was measured (areas shown in green in each accompanying schematic). Animals were approximately 6 months of age and values represent mean ± SEM (N = 6 males for each group). Statistical significance was determined by ANOVA followed by the BKY procedure. *p < 0.05, **p < 0.01, ***p < 0.001. WT Wild-type, MMP Matrix metallopeptidase, FAD Familial Alzheimer’s disease, MMP9KO MMP9 knockout, SEM Standard error of the mean, ANOVA Analysis of variance, BKY Benjamini, Krieger, and Yekutieli

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