Fig. 13

Analysis of Aβ-40 levels in the cerebrovasculature, plasma, and whole parenchyma brain fractions. Aβ-40 levels were examined in the A cerebrovasculature, B whole parenchyma, and C plasma of 5xFAD, 5xFAD/MMP9KO and 5xFAD/MMP9KO-het mice. Males and females were analyzed separately due to large differences in amyloid levels. Animals were approximately 6 months of age and values represent mean ± SEM (N = 12, 6 males, 6 females for each group). Statistical significance was determined by ANOVA followed by the BKY procedure. *p < 0.05, **p < 0.01, ***p < 0.001. Aβ Beta-amyloid, FAD Familial Alzheimer’s disease, MMP Matrix metallopeptidase, MMP9KO MMP9 knockout, MMP9KO-het MMP9KO heterozygous, SEM Standard error of the mean, ANOVA Analysis of variance, BKY Benjamini, Krieger, and Yekutieli