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Fig. 14 | BMC Neuroscience

Fig. 14

From: MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease

Fig. 14

Analysis of Aβ-42 levels in the cerebrovasculature and whole parenchyma brain fractions. Aβ-42 levels were examined in the A cerebrovasculature, and B whole parenchyma of 5xFAD, 5xFAD/MMP9KO and 5xFAD/MMP9KO-het mice. Males and females were analyzed separately due to large differences in amyloid levels. Animals were approximately 6 months of age and values represent mean ± SEM (N = 12, 6 males, 6 females for each group). Statistical significance was determined by ANOVA followed by the BKY procedure. **p < 0.01, ****p < 0.0001. Beta-amyloid, FAD Familial Alzheimer’s disease, MMP Matrix metallopeptidase, MMP9KO MMP9 knockout, MMP9KO-het MMP9KO heterozygous, SEM Standard error of the mean, ANOVA Analysis of variance, BKY Benjamini, Krieger, and Yekutieli

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